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    CRRT and plasmapheresis filters

    CRRT and plasmapheresis filters

    Appropriate for Ci-Ca® citrate and heparin anticoagulation

    • Steam sterilized
    • Long filter lifetimes
    • Excellent biocompatibility
    • Robust capillaries with minimal risk of blood leak
    • Filter size selectable to meet patient’s requirements

    Key features

    Steam-sterilization

    In the course of the INLINE-steam sterilization, the filters are continuously rinsed with 121°C hot, sterile steam for 15 minutes and dried thereafter. This process ensures:

    • Dialyzers free from residuals
    • Defined membrane characteristics
    Capillary

    An important safety aspect is the 100% leakage-testing of all filters, with just sterile water and sterile filtered air. This is only possible because of the special structure of the Fresenius Polysulfone® membrane – and the absence of pore filling agents like glycerin.

    All production steps from the manufacturing of the membrane up to the finished dialyzer are adjusted to each other resulting in constant highest quality.

    Ultraflux®

    AVpaed, AV400S, AV600S and AV1000S filters have different surface areas but the same reliable membrane. Substances with a molecular weight of up to approximately 30 kDa can be eliminated, while essential plasma proteins like albumin and cellular blood constituents are retained.

    The membrane of the Ultraflux® EMiC®2 is optimized to increase the removal of middle molecules.

    Ultraflux® EMiC®2 at a glance:
    High permeable pores and an adjusted cut-off of approximately 40kDa
    Increased clearance of myoglobin in rhabdomyolysis, or cytokines, interleukins and other factors elevated in sepsis
    Steep sieving coefficient curve closely mimics the glomerular basement membrane
    Narrows the gap to physiological renal function

    plasmaFlux®

    Simplified set-up due to dry delivery of P1dry and P2dry plasma filters
    Free passage of protein components even exceeding molecular weights of two million Dalton
    Retaining blood cells
    Double-layer membrane prevents blood cells from blocking fine pores
    Fresenius Polysulfone® with high biocompatibility

    EMiC®2

    Improved removal of middle molecules

    EMiC®2 filter and Ci-Ca® module
    EMiC®2 filter for the removal of middle molecules
    Enhanced Middle Molecule Clearance
    Cut-off at around ~ 40 kDa
    Advanced hollow fiber undulation technology ensures high efficacy due to homogeneous dialysate flow around the fibers
    Steep sieving coefficient curve closely mimics the glomerular basement membrane
    Substantially stable albumin levels
    High efficacy also at low blood flows

    Ultraflux® EMiC®2 benefits from modern membrane technology thanks to the higher permeability of its membrane and adjusted cut-off.

    Type Surface area Filling volume
    Ultraflux® EMiC®2 1.8 m2 130 mL 

    Ultraflux® AV

    Steam-sterilized Fresenius Polysulfone® Filters

    The Ultraflux® filters contain a Fresenius Polysulfone® membrane specifically developed for continuous renal replacement therapy. With this membrane, substances with a molecular weight of up to approximately 30kD can be eliminated. While plasma proteins like albumin, other large molecules and cellular blood constituents are retained. The filtration characteristics of this membrane come close to the natural human kidney’s function.
    Due to their high mechanical stability and excellent filter lifetimes, the Ultraflux® filters AV paed, AV 400S, AV 600S, AV 1000S are applicable for use in all continuous renal replacement treatments.

    The large inner lumen and thin wall thickness of the capillaries in the Ultraflux® filters improve the flow geometry and provide the following advantages:

    • Low flow resistance in the capillaries reduces friction and shear forces
    • High fluid exchange enables unrestricted ultra-filtrate flow
    • Excellent filter lifetime
    Type Surface area Filling volume
    Ultraflux® AV400S 0.75 m2 52 mL
    Ultraflux® AV600S 1.4 m2 100 mL
    Ultraflux® AV1000S 1.8 m2 130 mL
    Ultraflux® AVpaed 0.2 m2 18mL, luer-lock dialysate and filtrate ports

    plasmaFlux®

    plasmaFlux® - P1dry/P2dry

    plasmaFlux® - P1dry/P2dry
    Steam-sterilized dry plasma filter with two-layer membrane structure and modelled membrane topology
    Dry delivery enables simplified set-up with a shortening of the rinsing procedure
    Dedicated pores allow free passage of protein components such as immunoglobulins, lipoproteins and also other big molecules with molecular weights even those exceeding two million Dalton
    The membrane’s blood contact surface has a coarse-meshed topology that prevents blood cells from blocking fine pores; a stable filtration process at low TMP with excellent sieving coefficient is enabled
    Passage of blood cells through the membrane is prevented
    The surface layer inside of the capillary is surrounded and stabilized by a second homogeneous, fine-pored layer
    Fresenius Polysulfone® membrane offers excellent biocompatibility

    Two-layer membrane structure of P1dry/P2dry plasmafilter

    Electron micrograph of plasmafilters
    Left: Electron micrograph of P1dry/P2dry capillary with view into hollow fiber. Right: Magnified to show inner surface and cross-section of two layer membrane.

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