multiFiltratePRO

multiFiltratePRO acute therapy options	Ci-Ca^® CVVHD EMiC^®2 Ci-Ca^® CVVHD AV1000S Ci-Ca^® postCVVHDF Conventional heparin CRRT Therapeutic Plasma Exchange (TPE) Sepsis therapy
Ergonomic design	Large screen enables display of comprehensive information, e.g. therapy information or potential reasons in case of alarms The touch screen monitor has enhanced readability from various angles 4-wheel chassis with 2-stage locking system allows turning on the spot
Easy treatment application	Intuitive step-by-step instructions for relevant handling situations To ease handling in the ICU, fluid heaters are fully integrated into the device “Care-Mode” to prevent unnecessary alarms and to save time: temporarily decreased blood flow, stopped balancing system and extended pressure limits during patient care High capacity scales reduce the number of bag changes and thus user interactions
Comprehensive integrated Ci-Ca^® anticoagulation	Regional Ci-Ca^® citrate anticoagulation to minimize the risk of bleeding complications^1,2,3 Long effective treatment times allow for efficient fluid removal via low hourly fluid removal rates; this supports hemodynamic stability⁴ Ci-Ca^® avoids downtime, thus the delivered CRRT-dose is in accordance with the prescription⁴

Coupling of all active pumps through a single user interface:

Infused volumes of citrate and calcium solutions are automatically balanced with the filtrate pump
If the blood flow is changed, the device automatically adjusts the citrate pump
If the filtrate flow is changed, the calcium pump is adjusted accordingly
The citrate infusion continues for a reliable, limited period of time throughout bag changes (dialysate, substituate, filtrate). This helps to avoid an early coagulation of the system.

Supports the user with expert information and features
For routine adjustments of the Ci-Ca^® therapy, information from the protocol can easily be retrieved on the screen
In case of certain values set outside the standard range, the multiFiltratePRO makes the user aware of potentially risky clinical situations

Clear allocation of functionality

Dedicated pumps for citrate and calcium keep the syringe pump available for heparin application if needed during Ci-Ca® therapy. Separate level detectors and drip counters enable timely detection of empty bags, preventing air being transported downstream and enabling a smooth continuation of the treatment. During bag changes (dialysate, substituate, filtrate) the citrate infusion continues for a reliable period of time. This helps to avoid early coagulation of the system

Therapeutic plasma exchange is a well-established extracorporeal blood purification technique.

As described by Reeves et al., “the therapeutic effects of TPE could include the removal of pathological substances from the blood, such as monoclonal paraproteins and autoantibodies, as well as the replacement of deficient plasma components when plasma is used as a replacement fluid.” ⁵

Indications for TPE cover selected diagnoses from different specialities:⁵

Neurology
Hematology
Rheumatology
Nephrology

In contrast to separation via centrifugation, multiFiltratePRO separates the plasma from the blood cells via membrane plasma separation (MPS).

Easy set-up
Touchscreen-based interface guides the nurse through the entire setup, rinsing and priming.

Key information on the screen
Pressure display, exchanged volume and target plasma volume, treatment time, flow rates and pressure history.

Integrated automated plasma volume calculation
The patient’s plasma volume and the respective plasma exchange volume can be calculated by the plasma calculator of the multiFiltratePRO, according to Sprenger et al.⁶

Substitution fluid holder
Placed on the upper scale tray, the substitution fluid holder allows for easy bottle and bag handling at eye-level.

Two integrated substitution fluid heater bags
Two integrated substitution fluid heater bags gently warm the substitution solution to curtail the cooling of the patient.

Automated ramp-up of plasma separation
The multiFiltratePRO features a plasma to blood ratio ramp-up procedure to provide for a smooth start of plasma separation and stable filtration conditions⁷, while saving the user time, see figure 1: Plasma to blood ratio ramp-up.

The multiFiltratePRO includes a graphic user interface that monitors and displays all relevant set-up and treatment data. The integrated alarm system helps to quickly determine the urgency as well as the root cause of alarms.

The time until the next expected user action is displayed in the status bar at the top right of the screen. In addition, a list of further upcoming user interactions can be retrieved on the screen. Both help to optimize work processes in the ICU.

The “Care Button” switches the multiFiltratePRO into care-mode, by decreasing the blood flow, stopping the balancing system and extending the pressure limits. This will prevent unnecessary alarms when moving the patient or manipulating the catheter.

Attention

A perfect fit for every team

Key features | Ci-Ca | Therapeutic Plasma Exchange | Convenient handling

Key features at a glance